Human and Murine Models to Assess the Impact of Maternal Iron Status on Pre-eclampsia

DNS > O'Brien Lab > Human and Murine Models to Assess the Impact of Maternal Iron Status on Pre-eclampsia

Working on the project: Marisa Foehr, PhD

Specific Aims:

Determine if there are any differences in iron status between pre-eclamptic (BPH/5) and wild type (C57) mice before and/or during pregnancy
Determine if there are any differences in iron flux across the placenta, iron isotopic enrichment and protein expression profiles between pre-eclamptic (BPH/5) and wild type (C57) pregnant mice
Examine potential correlations between fetal growth, iron status and phenotypic severity of the BPH/5 mutant embryos
Determine if there are any plasma volume expansion defects in BPH/5 mice compared to C57 mice

Funded by: The College of Human Ecology Research Environmental Initiative Pilot Award Program to Encourage Multi-departmental Research Activities